Evan’s syndrome was 1st reported by Evans in 1951 and is defined as the consequent or subsequent occurrence of idiopathic thrombocytopenia (ITP) and autoimmune hemolytic anemia (AIHA). It is reported to occur most commonly in adolescents and rarely in adults. Pathogenesis suggests a defect in humoral and cell-mediated immunity. Its definitive management with corticosteroids or intravenous immunoglobulin (IVIG) has proved to be curative. Here we present a case of a 17-year-old female patient complaining of easy fatigability, abdominal pain, generalized weakness, ecchymosis, per rectal bleeding, and bruising being diagnosed by decreased hemoglobin, reticulocytosis, and increased immature platelet fraction, increased serum lactate dehydrogenase and positive Direct Coomb’s test. She was treated with prednisone and rituximab.