Background and Objective: Type 2 diabetes mellitus (T2DM) is a prothrombotic state induced by multiple mechanisms, and increased platelet activity being one of the important mechanisms among them. The aim of this study was to evaluate platelet indices in T2DM patients with and without overt complications and to assess their usefulness as markers of vascular complications in patients with T2DM.Material and Methods: A total 100 T2DM patients (50 with overt complications and 50 without any overt complication) were enrolled. Venous samples from the subjects were collected in EDTA tubes and analyzed with in 2 hours using the same automated cell counter (Mindray, Model BC-5800). Student t-test and Chi-square test were used to analyze the data.Results: MPV (Mean Platelet volume), PDW (Platelet Distribution Width), P-LCC (Platelet Large Cell Count) and P-LCR (Platelet Large Cell Ratio), were higher in T2DM patients with overt complications as compared to T2DM patients without overt complications, but the difference was statistically significant only for PDW (p = 0.305 for MPV; p = 0.01 for PDW; p = 0.653 for P-LCC; p=0.189 for P-LCR). MPV, PDW, P-LCC and P-LCR, were higher in T2DM patients with overt macrovascular complications (n = 41), versus T2DM patients without overt complications (n = 50), and the difference was statistically significant for MPV, PDW, and P-LCR (p =0.05 for MPV; p = 0.004 for PDW; p = 0.399 for P-LCC, p = 0.02 for P-LCR). No significant difference was noted in Plateletcrit (PCT) between different groups.Conclusion: MPV, PDW and P-LCR, tend to be higher in T2DM patients with overt macrovascular complications, as compared to T2DM patients without overt complications.
Sudhir Kumar Atri, Sonia Chhabra, Mohini, Gaurav Rathee, Vinay Singla. Platelet indices as surrogate markers of complications in T2DM patients. International Journal of Medicine Research, Volume 6, Issue 1, 2021, Pages 58-63