Concomitant use of policosanol and vitamins in older patients
Julio César Fernández-Travieso, José Illnait-Ferrer, Sarahí Mendoza-Castaño, Rafael Gámez-Menéndez, Ernesto López-González
Introduction: The efficacy and safety of policosanol have been investigated in clinical studies, included elderly patients. Policosanol is very safe and no drug-related adverse events have been demonstrated, even in population subsets with high consumption of concomitant therapy, indicating that the potential risk of drug-drug interaction for policosanol is low. The objective of the present analysis we investigatedwhether concomitant administration of policosanol with vitamins induces some specific adverse event or disturbance on any safety indicator in older patients with hypercholesterolemia. Methods: We randomised 1470 elderly patients at high coronary risk to policosanol or placebo for 3 years. For this analysis, the records of all patients (150) taking vitamins were included. Analysis was by Intention-to-treat. Results: Both groups were well matched at baseline. Policosanol significantly reduced low-density lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides and raised high-density lipoprotein cholesterol (HDL-C). Of 150 patients, 27 discontinued the study, 21/67 placebo and 6/83 policosanol patients. Of them, 16 patients (14 placebo, 2 policosanol) discontinued because of some adverse event. No disturbance of any safety indicator was found. The serious vascular adverse event in policosanol patients was lesser than in placebo. The frequency of moderate and mild adverse events in the policosanol group was lower compared with placebo group. Conclusion: It is concluded that policosanol therapy added to older hypercholesterolemic patients taking vitamins drugs produced relevant benefits on lipid profile and the frequency of serious adverse events respect to placebo, then indicated concomitant with vitamins in elderly, without increase any adverse event.
Julio César Fernández-Travieso, José Illnait-Ferrer, Sarahí Mendoza-Castaño, Rafael Gámez-Menéndez, Ernesto López-González. Concomitant use of policosanol and vitamins in older patients. International Journal of Medicine Research, Volume 5, Issue 3, 2020, Pages 65-71