Hyperpigmentation as a symptom of Vitamin B12 deficiency: A review
Introduction: Vitamin B12 (Cobalamin) deficiency is one of the most common vitamin deficiencies and is an important nutritional public health problem. Vitamin B12 deficiency presents as a variety of signs and symptoms. However, cutaneous manifestations of Vitamin B12 deficiency are often neglected. Skin hyperpigmentation is the most common cutaneous manifestation associated with vitamin B 12 deficiency. The article reviews the current knowledge on link between hyperpigmentation and vitamin B 12 deficiency Material and Methods: Pubmed database and Google scholar database were searched for Case reports, case series and mini reviews related to hyperpigmentation as a symptom of vitamin B12 deficiency. Results & Conclusion: Many studies mainly case reports have found an association of hyperpigmentation with vitamin B 12 but majority of them state it as a rare combination. From this review we find that pigmentation disorders due to vitamin B12 deficiency may be much more common than earlier thought. Therefore, all cases of hyperpigmentation should also be evaluated for Vitamin B12 deficiency. Studies have shown that hyperpigmentation due to vitamin B12 deficiency is reversible with adequate Vitamin B12 supplemental therapy.