Splenic vein thrombosis is a blood clot that is obstructing the splenic vein, which is located on the surface of the spleen. Reduced portal blood flow, a hypercoagulable state or vascular endothelial injury, abdominal trauma and after abdominal surgery can lead to splenic vein thrombosis. This study discusses about a 46 year old obese female patient who was presented in the general medicine department with abdominal pain after hysterectomy. CT abdomen shows the presence of fatty liver, small renal calculus and focal partial thrombosis of splenic vein which was diagnosed as splenic vein thrombosis. The study deals with the medical management of splenic vein thrombosis.