The work is based on the experience of surgical treatment of 427 patients with echinococcosis of the liver of various locations operated in the 2nd clinic of SAMI from 2003 to 2015. In the years 2003-2006. We operated 154 (36.1%) patients. These patients made up a control group. The comparison group included 134 (31.4%) patients operated in 2007-2010. The main group included 139 (32.5%) patients operated in 2011-2015. In comparison with 2003-2006. The incidence of postoperative complications decreased almost 5-fold - from 18.4% to 4.0%. Relapses of echinococcosis in the long term after surgery appeared in 12.9% of patients, and in the group of persons operated in 2003-2006, this indicator reached 28.2%. In subsequent years, against the background of intra- and postoperative prophylaxis of the disease, the number of relapses in the comparison group was reduced to 8.8%, and in the main group was reduced to zero. Among the main germicides, 80-100% glycerol, heated to 70 °C, does not cause destructive changes in the adjacent parenchyma, the brightest and quickest scolexic effect. In the surgery of liver echinococcosis, preference should be given to the topical mini-access, the possibilities of which can be significantly expanded by intraoperative ultrasound and video endoscopic assisting.