Aims and objective: To compare the spectrum of clinical presentation, demographic variables, circadian variation, risk factor, complications of coronary artery disease (CAD) among patients with and without diabetes.
Materials and Methods: Present study was done on 120 CAD patients at Chandulal Chandrakar Memorial Hospital, Bhilai from Sep., 2010 to Sep., 2012 after dividing patients in to Group D (n=60, diabetic CAD) and Group ND (n=60, non-diabetic CAD). Detailed history of all patients along with echocardiography, systolic and diastolic dysfunction, complications and mortality was recorded in both the groups. Unpaired student t test and chi-square test was used wherever required. P value of less than 0.05 was considered as significant.
Results: The most common age group was 55-64 years (33.33%) and 45-54 years (41.66%) in Group D and Group ND respectively. Mean age of male and female was 56±8.7 years, 55±10.2 years and 56.6±9.7 years, 54.2±9.1 years in Group D and Group ND respectively. Most of the patient in Group D and Group ND were having diabetes duration of 1-3 years (36.67%) and 5-10 years (20%) respectively. Risk factors such as stage 1 hypertension (31.66% vs 20%), stage 2 hypertension (23.33% vs 16.66%), high triglyceride (21.68% vs 3.33%) and low HDL-C (35% vs 23.33%) were mostly present in Group D whereas Pre-hypertension (18.33% vs 46.67%) and high LDL-C (18.33% vs 25%) were commonly recorded in Group ND. The most common symptoms were chest pain (85% vs 81.66%) followed by excessive sweating (61.66% vs 48.43%) and vomiting (40% vs 21.71%). Diurnal variation in cardiac events was present throughout the day in Group D whereas it was mainly observed during second quarter of the day in Group ND. In presents study, in Group D and Group ND, 18 (30%) and 8 (13.33%) patients have expired respectively. The most common cause of mortality was pump failure (pulmonary edema/cardiogenic shock/both) followed by fatal ventricular arrhythmia.Conclusion: Risk factors of CAD were more severe in patients with diabetes as compared to non-diabetes patients who were having CAD.