International Journal of Medicine Research

International Journal of Medicine Research


International Journal of Medicine Research
International Journal of Medicine Research
Vol. 1, Issue 2 (2016)

Correlation of erythropoietin and haematocrit levels in the anaemias of chronic kidney diseases: A study in federal medical centre, Umuahia, Nigeria


Obeagu Emmanuel Ifeanyi, Obeagu Gertrude Uzoma

The study was done to correlate the levels of erythropoietin(Epo) and haematocrit in some patients diagnosed with renal diseases in Federal Medical Centre,Umuahia,Abia State.A total of one hundred and eighty (180) subjects(90 males and 90 females) were recruited for the study.One hundred and twenty (120) subjects were recruited from those confirmed with renal diseases from the Urology Department of the hospital. Sixty (60) subjects (30 and 30 females) were predialysis chronic kidney disease patients,sixty (60) subjects (30 and 30 females) were chronic kidney disease patients on dialysis (D), and sixty (60) subjects (30 and 30 females) were the apparently healthy controls.Venous blood samples were collected from the subjects using aseptic standard method from the antecubital fossa.Serum samples were used for erythropoietin assay and EDTA anticoagualted blood used for Packed Cell Volume tests.Erythropoietin was determined by sandwich ELISA method and PCV was analysed by microhaemtocit method.The results were statistically analysed using student t-test and Pearson Product Moment method and statistical significance set at P<0.05.The result showed significant decrease (P<0.05) in Erythropoietin and PCV levels of predialysis subjects (23.3±3.2 iu/l, 16.0±1,4%) compared to Controls (48.6±24.0 iu/l, 43.8±4.9%) respectively and showed significant increase (P<0.05) in erythropoietin level of patients on dialysis (71.4±14.7 iu/l) compared to controls (48.6±24.0 iu/l) and significant decrease (P<0.05) in PCV level of dialysis subjects(27.0±7.0%) compared to control subjects(43.8±4.9%).The result also showed significant decrease (P<0.05) in Erythropoietin and PCV levels of predialysis subjects (23.3±3.2 iu/l, 16.0±1.4%) compared to dialysis subjects (71.4±14.7 iu/l, 27.0±7.0%) respectively.The correlation of erythropoietin and PCV levels showed perfect correlation in predialysis subjects and positive correlation in dialysis subjects.The study shows that Epo and haematocrit differ in predialysis patients.The difference could be due to the administration of recombinant erythropoietin to dialysis patients.
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How to cite this article:
Obeagu Emmanuel Ifeanyi, Obeagu Gertrude Uzoma. Correlation of erythropoietin and haematocrit levels in the anaemias of chronic kidney diseases: A study in federal medical centre, Umuahia, Nigeria. International Journal of Medicine Research, Volume 1, Issue 2, 2016, Pages 139-144
International Journal of Medicine Research