With the development of human societies, different medical systems have been evolved and developed according to the need of the society. It is a well-known fact that Traditional Systems of medicines always played an important role in meeting the global health care needs. They are continuing to do so at present and shall play major role in future also. The system of medicines which are considered to be Indian in origin or the systems of medicine, which have come to India from outside and got assimilated in to Indian culture are known as Indian Systems of Medicine (Prasad, 2002). India has the unique distinction of having six recognized systems of medicine and one of them is Unani System. In the last few decades there has been growing interest in alternative forms of therapy globally. These novel demands along with renewed popularity, traditional medical practices within India itself have created conflicting conditions for traditional medicine in general and for Unani in particular. Though allopathy and Unani System of medicine have their own strengths and limitations, an integrated approach brings the best of both to the patient and the nation. There are attempts by Unani researchers to integrate Unani system of medicine with modern medicine. There are certain constraints which need to be addressed before attempting integration. This article intends to give an overview of this exciting area of research.