Mastitis is one of the most prevalent costly diseases for dairy farmers and industry, resulting in a great deal of economic losses. Annual losses in the dairy industry due to mastitis was almost 2.37 thousand crore rupees in India. The level of infection that develops inside the udder of a cow is dependent upon many factors. Although mastitis is caused by various bacteria, viruses, fungi and prototheca, the most common cause are Gram-positive and gram-negative bacteria. Many different control measures of bovine mastitis include hygienic management procedures, antibiotic treatments, teat dipping sealants, and intramammary devises. The use of animals that are resistant to a determined disease reduces the need to apply drugs, with consequent decrease in the levels of contamination of products and the environment.