Aloe sp effects on the intestinal motility of Wistar rats
Patrícia Cincotto dos Santos Bueno, Claudia RP. Detregiachi, Sandra Maria Barbalho, Elen Landgraf Guiguer, Maricelma da Silva Soares de Souza, Cristóvam Emílio Herculiani, Jaqueline Rodrigues Gerondi, Jéssica Cisotto Machado, Bianca Lopes Bezerra da Silva, Bianca Luiza Forti Storti, Carolina Sanches Mattos, Daniele Ferreira Rocha
Aloe sp is a perennial shrub that grows in any type of soil and is native to Asia and East Africa and South America, but is acclimated in the world, preferring hot and humid climate. It may exhibit laxative effects due to the presence of anthraquinones. Considering this laxative effect, Aloe may be used in cases of constipation. The present study aimed to evaluate the effects of Aloe sp on the intestinal motility in Wistar rats. Male rats were fasted for 12 hours and then they were divided in three experimental groups. The Control group 1 (G1) was treated with 1 mL of water by gavage route (n=7); Group 2 (G2) was treated with Senne tea at the ratio of 1:1 in water by gavage route (n=07), and Group 3 (G3), was treated with Aloe tea at the ratio of 1:1 in water by gavage route (n = 8). Senne tea was used for comparison of the intestinal motility. After 45 minutes, the groups received 1 mL of activated charcoal suspension. After 4 hours the animals were submitted to euthanasia and the abdominal cavity was opened and the intestine was removed and fixed with pins on a Styrofoam board. The intestinal length and the distance covered by the activated charcoal was measured in all groups. Our results showed that the animals of the three experimental groups were similar (p>) in the weight, in the intestinal length and the in distance traveled by the activated charcoal. Comparing the intestinal motility between G1, G2 and G3, the better results were obtained in G2 (Senne group) when comparing to control (p = 0.001). Our results show that Aloe did not promote increase in the intestinal motility in Wistar rats contradicting its effects in folk medicine and in some studies found in the literature.