Guidelines for management of pulmonary hypertension in specific patient situations
Dr. Naresh Sen, Dr. Sonal Tanwar
The options for pharmacotherapy in patients with PAH include several drug classes and delivery routes. The choice of therapy should be made by experienced clinicians and must be based upon an appropriately established diagnosis and evaluation of the patient’s disease severity. Available evidence is sufficient to inform a limited number of strong guideline recommendation statements regarding the effect of a specific therapy or combination of therapies on select outcomes in distinct groups of patients defined according to disease severity. Where current evidence is insufficient to inform strong guideline recommendations, expert consensus may provide reasonable advice in evaluating available data and reasonable therapeutic choices. Well-designed studies are needed to compare approaches to therapy in specific groups of patients. As such information and new therapies become available, a reassessment of appropriate clinical advice for the pharmacologic therapy for adult patients with PAH will be required.