International Journal of Medicine Research

International Journal of Medicine Research


International Journal of Medicine Research
International Journal of Medicine Research
Vol. 4, Issue 3 (2019)

Liver function in Thalassemia Major


Dr. Iman Abdul Wahhab Hasan, Dr. Basma Jasim Obaid, Dr. Muntaha Mohammed Murad

The study of liver function tests in thalassemia major patients was done. The aim of the study to see the extend liver damage in thalassemic patients. Liver function were estimated in group of 50 thalassemic patients and the results were compared with the results obtained in group of age and sex matched control with normal Hb (HbAA). The liver function were elevated in 32 Thalassemic patients and the remain 18 patients were within normal range, E.I. 64% of the patients got SGOT and SGPT elevation from both sexes. The Alkaline phosphatase was elevated in 52% of cases and there was P.T. time prolongation in 16% of cases. Liver functions were considerably higher in thalassemic patients and the different in their mean compared to the mean in the normal group (HAA) was statistically significant (P<0.05), It is suggested that further studies are necessary on liver functions tests on Iraqi Thalassemic patients particularly on older age to assess the extent of liver damage in the Thalassemic patients. Liver functions were elevated mostly in Thalassemic patients after the age of 6 years 68.5% while 31.5% before that age. SCOT and SGPT were mainly elevated with the same value in both sexes. While S-Alkaline phosphatase and pT were elevated in Males > Females. Liver functions were elevated after splenectomy in 64% of thalassemic patient with splenectomy. 86% of the Thalassemic patients included in the study were relatives while 14% were unrelated (Father &. Mother). Liver size is increased in 96% of the cases. 100% of patients got pallor with Hb ranges 5-10g/dL. Linear growth was affected and was more influenced children after the age of 8 years. The age of the Thalassemic patient in the study ranges between 1.3 year > 16 years.
Pages : 63-67