Anti-diabetic activities of theo broma cacao ethanolic seed extract on streptozotocin induced diabetic wistar rats
Ukpanukpong RU, Eban LK, Olaluwoye AF, Aigbadumah PO
The study was aimed at investigating the antidiabetic activities of Theobroma cocao ethanolic seed extract on streptozotocin induced female wistar rats. A total of 40 rats were used and designated into six study groups of 8 rats per each group. Non-diabetic rats were administered distilled water, diabetic control group was induced with 60mg/kg of streptozotocin, diabetic treated group was treated with insulin while extracts treated groups were administered 75mg, 150mg and 300mg of Theobroma cacao seed extract respectively. Treatment was done orally for 14 consecutive days. Body weight indices and blood glucose levels were monitored during treatment and recorded. Animals treated with Theobroma coaca and insulin showed reduction in glucose concentration compared with diabetic control group. Heamtological indices significantly affected. There was a significant reduction in the low density lipoprotein of the treated groups compared with non-diabetic group, tricacylglyceerides was decreased, high density lipoprotein was not significantly increased in insulin treated group but it was increase significantly in the Theobroma coaco treated groups. Low density lipoprotein was significantly reduced in treated groups while it was raidsed in diabetic group. Serum enzymes ALT. AST and ALP were elevated in the STZ induced diabetic rats compared with non-diabetic control and there was a reduction in the liver enzymes os the treated groups. Serum albumin was increased in the diabetic rats, from this study, results show the Theobroma cacao seed extract lowers blood glucose level, improved serum enzymes and lipid profile activities in STZ Induced diabetic rats.