Vol. 4, Issue 2 (2019)
Influence of L-arginine (Tivortin®) on imbalance of essential amino acids of blood plasma in patients with stable angina pectoris
Author(s): Bogdan TV, Lisohub VG, Bogdan VV
Abstract: Patients with stable angina (SA) were examinedwith applicationmethod of ion-exchange liquid-column chromatography. In the blood plasma the content of essential amino acids (EAAs) was determined: arginine, valine, histidine,isoleucine, leucine, lysine, methionine, threonine, tryptophan, phenylalanine.The patients are divided into two groups: I group - 33 persons who receivedcardcet, bisoprolol, atoris, enap, acetylsalicylic acid, clopidogrel;ІІ - 35 people, the therapy of which, in addition to the named drugs, included 10 infusions by100 ml of L-Arginine (Tivortin®), Yuria-Farm). The control group included 20clinically healthy individuals.The results of the study indicate a different dynamics of changes in the level of EAAs inblood plasma in patients with SA who received antianginal therapy andantianginal therapy with L-arginine.It should be noted that in patients with Group I after treatment, the level of EAAs has significantly decreased, and in patients of the II group - has significantly increased comparativelywith values before treatment. In patients with SA who received baseline therapyand L-arginine, in contrast to patients receiving baseline therapy, inblood plasma normalizes the level of arginine that promotes the synthesis of NO;the level of amino acids (AA) with branched side chain normalized(valine, leucine and isoleucine), which provide synthesis of large quantitiesnecessary compounds (peptides, sterol, ketone bodies, glucose); a normal level of lysine was maintained, which contributes to adequate flowmetabolic transformations of this AA.Against the background of receiving baseline therapy and L-arginine in patients with SAcompensatory replenishment and intravascular retention were notedlevel of histidine with its enhanced intracellular metabolism.Thus, the use of L-arginine in a complex treatmentpatients with SA corrects an unbalanced AA of plasma, and therefore, favorableaffects the improvement of physiological processes in conditions of myocardial ischemia.