Vol. 4, Issue 2 (2019)
Comparing the effectiveness of rapid Non-structural glycoprotein-1 (NS1) test antigen detection kit with IgM ELISA: A prospective study
Author(s): Dr. Satish Chandel, Dr. Nitin Nahar, Dr. RS Maniram, Dr. TN Dubey
Abstract: Background: Early diagnosis of dengue virus (DV) infection is important to improve clinical outcomes. Non-structural glycoprotein-1 (NS1) has proven to be a useful biomarker for early diagnosis of dengue. Aims and Objectives: To evaluate rapid NS1 antigen card test and compared with IgM ELISA for early dengue diagnosis in acute febrile illness. Materials and Methods: Hundred patients with acute febrile illness were studied in the Department of Medicine Gandhi Medical College and associated Hamidia Hospital Bhopal. Patients were studied for NS1 antigen using rapid NS1 antigen detection kit and compared it with IgM ELISA test results. USG abdomen and Chest X-ray were also performed in each patients. Results: Mean age of patients of acute febrile illness was 29.94±13.23 years with male male preponderance (61%). Majority had duration of fever for 4-5 days (35%). 64% patients were found positive for NS1 antigen. IgM dengue test was positive in 57% patients. Sensitivity and specificity of NS1 antigen was 53.1% and 36.1% respectively. Positive predicting value and negative predicting value of NS1 antigen test was 59.6% and 30.2% respectively. Conclusion: Though insignificant NS1 antigen test had lower sensitivity and specificity compared to IgM ELISA test. Previous studies are in agreement with our findings. However, NS1 antigen test has several advantages over IgM ELISA test.
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