Vol. 4, Issue 2 (2019)
Evaluation of platelet count and indices in patients of sepsis
Author(s): Dr. Sudhir KR Atri, Dr. Sonia Chhabra, Dr. Vinay Singla, Dr. Mohini, Dr. Gaurav Rathee, Dr. Lakshmi Priya
Abstract: Introduction: Platelet indices like Mean Platelet volume (MPV), are readily available blood tests, although their prognostic value in patients with sepsis has not been fully explored. This study aims to explore the behavior of platelet indices in sepsis and their clinical prognostic value. Aim and Objectives: To study the various platelet indices - Mean platelet volume (MPV), Platelet distribution width (PDW), Plateletcrit (PCT) and Platelet large cell ratio (PLCR) in patients of sepsis and correlation of platelet count and indices with severity of sepsis. Material and Methods: A total of 50 patients diagnosed with Sepsis were included in the study. All of them were thoroughly evaluated in terms of routine and specific biochemical investigations and complete blood count including platelet indices like mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) and platelet large cell ratio (PLCR). To establish the diagnosis of Sepsis, SIRS (Systemic Inflammatory Response Syndrome) criteria were followed. The cases were divided into Survivors and Non survivors (who expired during the treatment process). Results: Mean platelet counts in the Survivors group and Non-survivors group were 203.305±39.84 x 109/L and 121.92±43.55 x 109/L respectively. The Mean platelet volume among the Survivors and Non-survivors group in the present study were 8.72±0.96 fL and 11.46±0.98 fL respectively. Mean Platelet distribution width value in Survivors group was 12.79±2.02 and in Non-survivors groups it was 15.67±0.85. The Mean plateletcrit values in Survivor and Non-survivor group were 0.23±0.05 % and 0.19±0.07 % respectively. The p value was found to be significant in case of Platelet counts, MPV and PDW among the Survivors and Non-survivors group Conclusion: A statistically significant difference was seen between survivors and non-survivors for platelet indices which make the platelet indices easily available, cheap and useful prognostic markers for patients in septic shock.