Vol. 4, Issue 1 (2019)
Renal complications in contrast studies
Author(s): Chaitanya Lodha, Supriya Barsode, Dr. Uday Gokhale, Salomi Bhandare, Sneha Roy
Abstract: Objective: To evaluate the effect on renal function, assess the outcome in patients undergoing contrast based procedures and establish relationship of comorbidities with contrast induced nephropathy (CIN). Material and Method: A cross-sectional observation study conducted on 1100 patients admitted in a tertiary hospital was included. Patient’s baseline and post-procedure creatinine were obtained to estimate the incidence of contrast induced nephropathy. Result: 27.3% of study population were observed to have CIN, with an increased risk in those with high BMI and those above the age of 40 years. Statistically significant proportion of female population was observed to have CIN. Hypertension and combination of comorbid conditions was significantly associated with CIN. A linear relationship was observed between dose and CIN. Gadolinium based contrast media was found to be safer as compared to iodine based contrast media. Positive cases had a significantly higher baseline and post-procedure serum creatinine and eGFR values (p<0.001) Conclusion: Pre-existing renal impairment plays a significant role in CIN and should be considered as a major pre-disposing factor. Hypertension, Diabetes Mellitus and those on nephrotoxic nonsteroidal anti-inflammatory drugs have a direct effect on the renal functioning and hence. Being a dose-dependent phenomenon, gadolinium based contrast media are safer than iodine based contrast media. In India, not many studies have been performed to know the incidence of CIN. This study focuses on studying the incidence and risk factors associated with contrast induced nephropathy.
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