Vol. 4, Issue 1 (2019)
A cross-sectional study on antioxidant status in trauma patients with wound healing disorders
Author(s): Dr. Hemlata Gupta, Dr. Ram Krishna Gupta
Abstract: Background: Disorders in wound healing (DWH) are common in trauma patients, the reasons being not completely understood. Inadequate nutritional status may favour DWH, partly by means of oxidative stress. Objective: To investigate the status of markers of anti-oxidant in patients with DWH within routine setting. Methods: a cross-sectional study was conducted in 44 trauma patients with DWH in addition to markers of pro-/antioxidant balance (antioxidant capacity, peroxides, and malondialdehyde). Epi-info was used as software. Statistical significance was set at P < 0.05. Results: Mean concentrations of β-carotene (0.6± 0.4 μmol/L), selenium (0.79±0.19 μmol/L) were relatively low. Most patients showed levels of selenium (≤ 94 μmol/L; 71%) and β-carotene (<0.9 μmol/L; 86%) below the reference range. Plasma antioxidant capacity was decreased, whereas peroxides and malondialdehyde were increased compared to normal values. Inverse correlations were found between CRP and albumin (P<0.05) and between CRP and prealbumin (P<0.01). Conclusions: Trauma patients with DWH frequently suffer from protein malnutrition and reduced plasma concentrations of anti-oxidant and oxidative burden. Thus, adequate nutritional measures are strongly recommended to trauma patients.
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