Vol. 3, Issue 4 (2018)
The effects of long-term haemodialysis on red cell distribution width, haemoglobin, fibrinogen, D-dimer and survival outcome
Author(s): Derry Heppy Fritiwi, Harun Rasyid Lubis, Adi Koesoema Aman, Stephen CL Koh, Herman Hariman
Abstract: Background: Haemodialysis has become an increasingly safe and well-tolerated long-term maintenance therapy for end-stage renal disease. However, the highest mortality rate was found within the six months of initiating dialysis commonly due to cardiovascular disease. The aim of the study is to determine the effects of long-term haemodialysis on red cell distribution width, haemoglobin, fibrinogen, D-dimer, urea reduction and survival outcome. Materials and Methods: 50 patients on long-term haemodialysis were recruited (males n=30, females n=20). Their mean age was 50.4 ± 12.4 years ranging between 18 and 68 years old. Blood sampling was performed before and after haemodialysis; haemoglobin, RDW, fibrinogen, D-dimer and urea reduction percentage were determined. Results and Discussion: No statistically significant differences in haemoglobin, RDW and D-dimer before and after haemodialysis except for elevated fibrinogen (P=0.04) and urea reduction percentage (P=<0.001), similarly no significant differences between those who died and still living were found. Wide variations in the parameters studied could account for these differences. Eleven patients died (22%) and ten (91%) within 18 months and 5.5 years and the last one (9%) after 8.75 years of haemodialysis. Conclusion: Wide variations in the parameters studied were seen. No clear indication as to which markers are responsible for survival outcome and may be other unknown factors are involved.