Relation of CIMT to various Micro & Macro-vascular complications of Diabetes
Dr. Ambrish Avate, Dr. Sachin Shivnitwar
The basic pathology that relates complications of Diabetes with blood sugar levels is atherosclerosis. The basic mechanism that is responsible for atherosclerosis in Diabetics is non-enzymatic reaction between glucose and proteins or lipoproteins in arterial walls. This ultimately leads to the formation of form Advanced Glycosylation End products (AGEs). Once formed, AGE-protein adducts are stable and virtually irreversible. After initial screening, demographic details of the patient like patient identifier, age, gender, height, weight, smoking history, alcoholism history were recorded in case record form (CRF). Other relevant history like history of coronary artery disease (CAD), history of stroke or transient ischemic attacks (TIAs), history of peripheral arterial disease, autonomic neuropathy, retinopathy and renal disease was also noted in CRF. Mean values of CIMT in patients with and without macrovascular complications were non-significant for CAD [0.93 ± 0.04 vs 0.91 ± 0.06 (p=0.341)], CVA [0.92 ± 0.03 vs 0.91 ± 0.06 (p=0.691)], and PVD [0.93 ± 0.02 vs 0.91 ± 0.06 (p=0.225)] respectively. Glycemic parameters like FBS, PPBS, HbA1c and duration of diabetes were significantly associated with occurrence of retinopathy and nephropathy.