Background: Infants (<28 days) are often suffered from neonatal sepsis. Neonatal sepsis is an important cause of morbidity and mortality in newborns.
Aims and Objectives: To evaluate incidence and risk factors for mortality of newborns with sepsis admitted in NICU.
Materials and Methods: Hundred neonates were studied in the Department of Pediatrics, People’s College of Medical Sciences and Research Centre, Bhopal admitted with probable sepsis. Maternal conditions, neonatal physical condition, investigations and follow up till patient was either discharged or die were collected. Complete blood count (CBC), CRP and Blood C/S, Bed side RBS, LP, X-ray chest, serum electrolytes, ABG etc. were done and compared with patients outcome. P value of <0.05 was considered as significant.
Results: Female preponderance was observed (70%) with mortality rate of 16%. Patients who were died most of them were having, needed chest compression (76%) (p=0.021), birth weight <1000 gms (37.5%) (p<=0.002), TLC <5000 (56.2%) (p=0.021), platelet count <50000 (75%) (p=0.003), toxic granules were present (75%) (p=0.028) and needed SIMV (100%) (p=0.001) as compared to patients who had survived.
Conclusion: Mortality rate was high in neonatal sepsis patients. EOS, patients requiring resuscitation at birth, pre-maturity, LBW patients, Leucopenia (TLC < 5000), thrombocytopenia, hypothermia, hypokalemia and SIMV support were the main risk factors associated with mortality.