Background: Urinary tract infections (UTIs) are common in both diabetic and non-diabetic patients. Antimicrobials susceptibility for microorganisms causing UTI varies from place to place and time to time, hence it is important to screen the treads and susceptibility pattern of predominant organisms against antimicrobials.
Aims and Objectives: To determine the spectrum of uropathogens and antibiotic sensitivity pattern in patients with and without diabetes (DM) in patients with clinically suspected UTI.
Material and Methods: Two hundred patients with UTI were studied with clinically diagnosed UTI, attending both outpatients and inpatients of AIIMS Bhopal, Madhya Pradesh from February 2016 to December 2017. Two groups were formed as Group A (n=100; patients with DM) and Group B (n=100; patients without DM). All samples and isolates were investigated by standard laboratory procedures.
Results: A total of 32.5% samples showed significant growth. No significant difference among culture positivity rate was noted between Group A and Group B (36.4% Vs 25.6%). Escherichia coli were the most frequent organism (65.6% in Group A and 67.8% in Group B). Gentamycin and nitrofurantoin were highly sensitive to E. coli isolated in diabetic patients among the tested antimicrobials followed by cotrimoxazole, norfloxacin and ciprofloxacin. Least sensitivity rate was observed with ampicillin and cephalexin. However, no difference was noted on the sensitivity pattern of the antimicrobials among E. coli isolated between group A and Group B.
Conclusion: High proportion of gram negative bacilli with predominant uropathogen being E. coli was noted. Irrespective of the status of diabetes, Staphylococcus sps and Pseudomonas sps were not isolated from UTI patients in our study. The isolation of organisms and their resistance pattern was almost similar between diabetic and non-diabetic patients.