Vol. 3, Issue 1 (2018)
Correlation of thyroid function with lipid parameters in patients with diabetes and hypertensive diabetes: A prospective study
Author(s): Manuj Sharma, Ashwin Dk, Shikha Sharma
Abstract: Background: Lipid and thyroid function abnormality is commonly observed in patients with type 2 diabetes mellitus (T2DM). Both hypothyroidism and hyperthyroidism are the reasons to develop secondary dyslipidemia. Aims and objective: To study the thyroid function and its correlation with the lipid parameters in patients with diabetes and hypertensive diabetics. Materials and Methods: A total 140 T2DM patients were studied in the Department of Endocrinology, Gandhi Medical College, Bhopal between January 2016 to December 2017. Patients were divided into Group A (n=42, patients having diabetes only) and Group B (n=98, patients having diabetes with hypertension). Detailed demographic parameters, glycemic parameters including fasting plasma glucose (FPG), post prandial glucose (PPG), glycated hemoglobin (HbA1c) and average blood glucose were estimated. Thyroid function test viz. T3, T4 and TSH along with lipid parameters were estimated for all the patients. Results: Out of 140 patients, 29.78% were diabetics whereas 70.22% were hypertensive diabetics. Male preponderance was recorded in both Group A (80.95%) and Group B (76.76%). HbA1c (p=0.001) and average blood glucose (p=0.023) was higher in Group A. Thyroid function test was comparable between both the groups but correlation of lipid parameters with the thyroid function test parameters has revealed that LDL-C was positively correlated with T3 (r=0.303, p=0.0004), T4 (r=0.181, p=0.036) and TSH (r=0.184, p=0.034). VLDL-C was also positively correlated with the T3 (r=0.201, p=0.021). Conclusion: Positive correlation was obtained between LDL-C and T3, T4 and TSH and VLDL-C with T3 which highlight the importance of screening thyroid function among diabetes patients with or without hypertension.