Reduced antioxidant potential (AOP) of LDL with increased waist circumference (WC): Predisposing factors for coronary heart disease in post-menopausal women
Dr. Nivedita Singh, Dr. Sanjeev Kumar Singh, Dr. Neelima Singh
Objective: Changes in sex hormone during the menopausal transition are thought to have an important impact on weight gain. Visceral adiposity is more common in post-menopausal women, is measured by Waist circumference (WC). Coronary heart disease (CHD) is a major complication in post-menopausal women. The peroxidation of lipoproteins, especially low density lipoproteins (LDL) play a significant role in the pathogenesis and progression of atherosclerosis. This peroxidation reaction is countered by antioxidants present in LDL known as its antioxidant potential (AOP). Methods and Results this study was carried out in 100 women ranging in age from 20 to 65 yrs. All women were categorized into two groups. 54 of the women were postmenopausal, aged between 40-65 years, while 46 of the women were pre-menopausal (20-35 year). AOP of LDL was measured in isolated LDL by xanthine oxidase system. AOP was significantly decreased (p < 0.05) in postmenopausal group compared to premenopausal group. A significant negative correlation (p < 0.001) was found between WC and AOP. Conclusion These results demonstrate that post-menopausal women experience increased cardiac risk that could be due to decreased AOP of LDL highly relating with increased WC. Therefore AOP of LDL can serve as a predictor for future cardiac events in post-menopausal women.