Vol. 1, Issue 4 (2016)
Impact of chronic toxoplasmosis invasion on immunological parameters in HIV-infected people receiving antiretroviral therapy
Author(s): Hryzhak Іhor Hnatovich
Abstract: The features of effectiveness of antiretroviral therapy are unknown in HIV-infected persons with chronic Toxoplasma gondii invasion. Under supervision for three years there were two cohorts of HIV-infected persons – 531 seropositive patients for Toxoplasma gondii and 345 – persons with seronegative status for Toxoplasma. The laboratory monitoring for number of CD4+T-lymphocytes and viral load of HIV RNA were conducted in all patients. Statistical data processing was carried out on the PC with the definition of Student's t-test. Found that the number of patients out seropositive for toxoplasmosis cohort who received antiretroviral therapy were by 12.38% less than in seronegative cohort (Р<0,0001). This phenomen may be the result of exposure toxins Toxoplasma on neurotransmitter processes in the brain and cause inappropriate decisions regarding their own health. The viral load of HIV RNA in both cohorts are similar at the end of supervision. During three years the number of CD4 + T lymphocytes in seropositive cohort remained unchanged, unlike in seronegative individuals this indicator significantly increased from 400,93±13,34 to 473,03±14,95 cell/μL (P1<0,001) and it was by 48,82 cell/μL more than persons in seropositive cohort. Thus, HIV-positive people which infected by Toxoplasma gondii less frequently take ART then patients without Toxoplasma invasion and they have the insufficient immunological efficacy of ART.
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